• 陈翠霞(教授)

    发布时间:2017-03-05作者:浏览次数:3580

    ?姓名: 陈翠霞

    ?职称: 教授

    ?系属: 化学工程学院

    ?最高学位: 博士

    ?学科: 生物化工、生物工程与医药

    ?所学专业:细胞生物学

    ?电子邮箱:chencx@upc.edu.cn

    ?联系电话:0532-86981561

    ?地址邮编:山东省青岛市黄岛区长江西路66号中国石油大学(华东)化学工程学院,266580

    ?个人主页:

    学习与工作经历

    学习经历:2002-2007:东北师范大学细胞与遗传研究所 研究生

    1998-2002:聊城大学生命科学学院 本科

    工作经历:2016.12- 至今:中国石油大学(华东)教授

    2014.8-2015.8:英国曼彻斯特大学 访问学者

    2010.12-2016.12:中国石油大学(华东)副教授

    2007.7-2010.12:中国石油大学(华东)讲师

     ◎研究方向

    1. 多肽自组装及其多肽纳米颗粒结构与功能之间的关系研究

    2. 新型多肽类生物材料(抗菌、抗肿瘤及抗细菌生物膜短肽肽;止血、组织工程肽水凝胶等)的设计及在生物医学等领域的应用

    3. 抗菌肽与表面活性剂之间的相互作用及在日化产品中的应用研究

    承??蒲锌翁?/strong>

    1.硅藻壳的大量制备及其在生物医药领域的应用研究,中央高校自主创新科技专项,18CX05012A,18万,在研。

    2.FNS007自组装研究,校企联合,13万,在研。

    3.(AABB)na-螺旋肽的从头设计及抗肿瘤和细胞选择性机理研究,国家自然科学基金面上项目,31271497,85万,结题。

    4.青年教师骨干项目,8万,结题。

    5.(XXYY)nα-螺旋肽的设计及抗菌功能研究,校自主创新项目,27R1204028A,7.5万, 结题。

    6.AxK短肽的自组装行为及抗肿瘤活性研究,山东省自然科学基金青年基金,ZR2009DQ001,4万,结题

    7.AmKn自组装短肽的抗肿瘤活性研究,国家自然科学基金青年基金,30900765,20万,结题

    代表性论文和专利

      1. 代表性论文:

    (1)Cuixia Chen,Jingxin, Wang, Ruirui Hao, Zheng Wang, Yurong Zhao, Cheng Zong, Hai Xu, Transglutaminase-Triggered Gelation and Functionalization of Designed Self-Assembling Peptides for Guiding Cell Migration, ACS Appl. Bio Mater. 2018, 1, 6, 2110-2119.

    (2) Cuixia Chen, Yu Zhang, Zhe Hou, Xuejing Cui, Yurong Zhao,Hai Xu, Rational Design of Short Peptide-Based Hydrogels with MMP-2 Responsiveness for Controlled Anticancer Peptide Delivery, Biomacromolecules 2017, 18, 11, 3563-3571

    (3) Cuixia Chen, Jing Hu,a Cheng Yang, Yu Zhang, Fang Wang, Quanmeng Mu, Fang Pan,b Hai Xu and Jian Ren Lu,Amino acid side chains affect the bioactivity of designed short peptide amphiphiles, J. Mater. Chem. B, 2016, 4: 2359-2368

    (4) Jingkun Bai, Cuixia Chen, Jingxin Wang, Yu Zhang, Henry Cox, Jing Zhang, Yuming Wang, Jeffrey Penny, Thomas Waigh, Jian R. Lu, and Hai Xu,Enzymatic Regulation of Self-Assembling Peptide A9K2 Nanostructures and Hydrogelation with Highly Selective Antibacterial Activities, ACS Appl. Mater. Interfaces, 2016, 8 (24):15093–15102

    (5) Cuixia Chen, Yu Zhang, Rui Fei, Changhai Cao, Meng Wang, Jingxin Wang, Jingkun Bai, Henry Cox, Thomas Waigh, Jian R. Lu, and Hai Xu, Hydrogelation of the short self-Assembling peptide I3QGK regulated by transglutaminase and use for rapid hemostasis, ACS Appl. Mater. Interfaces2016, 8 (28):17833–17841

    (6) Cuixia Chen, Cheng Yang, Yucan Chen, Fang Wang, Quanmeng Mu, Jing Zhang, Zongyi Li, Fang Pan, Hai Xu, and Jian Ren Lu,Surface Physical Activity and Hydrophobicity of Designed Helical Peptide Amphiphiles Control Their Bioactivity and Cell Selectivity, ACS Appl. Mater. Interfaces2016, 8 (40), 26501–26510. 

    (7)Cuixia Chen, Yucan Chen, Cheng Yang, Ping Zeng, Hai Xu, Fang Pan, and Jian Ren Lu,High Selective Performance of Designed Antibacterial and Anticancer Peptide Amphiphiles, ACS Appl. Mater. Interfaces 2015, 7:17346?17355

    (8) Cuixia Chen, Jing Hu, Ping Zeng, Yucan Chen, Hai Xu, and Jian R. Lu,High Cell Selectivity and Low-Level Antibacterial Resistance of Designed Amphiphilic Peptide G(IIKK)3INH2, ACS Appl. Mater. Interfaces 2014, 6:16529?16536. 

    (9) Cuixia Chen, Jing Hu, Ping Zeng, Fang Pan, Mohammed Yaseen, Hai Xu ,Jian R. Lu,Molecular mechanisms of anticancer action and cell selectivity of short a-helical peptides, Biomaterials 2014, 35:1552-1561. 

    (10) Cuixia Chen, Yanfeng Gu, Li Deng, Shuyi Han, Xing Sun, Yucan Chen, Jian R. Lu, and Hai Xu,Tuning Gelation Kinetics and Mechanical Rigidity of βHairpin Peptide Hydrogels via Hydrophobic Amino Acid Substitutions,ACS Appl. Mater. Interfaces 2014, 6:14360?14368. 

    (11) Hai Xu, Cuixia Chen, Jing Hu, Peng Zhou, Ping Zeng, Changhai Cao, Jian R Lu, Dual modes of antitumor action of an amphiphilic peptide A9K, Biomaterials2013, 34(11): 2731–2737.

    (12)Cuixia Chen, Jing Hu, Shengzhong Zhang, Peng Zhou, Xichen Zhao, Hai Xu、Xiubo Zhao, Mohammed Yaseen, Jian R Lu, Molecular mechanisms of antibacterial and antitumor actions of designed surfactant-like peptid, Biomaterials, 2012, 33(2): 592-603. 

    (13)  Jing Hu, Cuixia Chen, Shengzhong Zhang, Xichen Zhao, Hai Xu, Xiubo Zhao, Jian R. Lu, Designed antimicrobial and antitumor peptides with high selectivity, Biomacromolecules2011, 12(11): 3839-3843. 

     ◎专利
    3年来,授权专利6项,如下:

    (1)一种两亲性自组装超短肽纳米止血材料,专利号:ZL 201510590566.9,授权公告日:201654日,发明(设计)人:陈翠霞,徐海, 张宇, 白景琨 王景新, 吕建仁

    (2)一种新型抗菌肽,申请号:201310328915.0,专利号:ZL201310328915.0,发明(设计)人陈翠霞,徐海,吕建仁,胡婧,授权公告日:2016113日。

    (3)一种可用于细胞粘附的水凝胶及其制备方法,申请号:201510830665.x,发明(设计)人:陈翠霞,徐海,王景新,张宇,白景琨,授予专利日:20161014日,分类号:A61L 27/22

    (4)一种FeCl3调控的智能型多肽水凝胶、制备方法及其应用,申请号:201510830551.5 ,分类号:A61L 27/22,发明(设计)人:陈翠霞,徐海,白景琨,张宇,王景新,授予专利日:20161014

    5一种制备水凝胶的多肽,专利号:CN201610166119.5,专利发明人:陈翠霞,徐海,张宇,授予专利日:2019-11-8

    6)一种制备水凝胶的多肽及其制备的水凝胶,专利号:CN105669832B,授予专利日陈翠霞,徐海,张宇:2019-02-26

    学术兼职

    Biomacromolecules, ACS Appl. Mater. Interfaces,ACS Omega等期刊审稿人

    指导研究生情况

    硕士生:2019级:王琛,廖啸天;2018级:王彤,朱钰婷 2017级:徐明璐;2015级:侯哲,牟泉萌,毛雅迪(协助指导);2014级:王芳;2013级(协助指导):张宇,王景新,杨成;2012级(协助指导):陈玉璨;2011级(协助指导):曾平;2010级(协助指导):张胜中

    博士生(协助指导):2017级:彭晓婷;2015级:张江玉;2012级:白靖琨;2008级:胡婧




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